Improving Robust High-Dimensional Causal Inference and Prediction Modelling

Lead by Celia M.T. Greenwood, Full Member, McGill Centre for Translational Research in Cancer, Senior Investigator.
Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research.
Associate Professor, Departments of Oncology, and Epidemiology, Biostatistics and Occupational Health, and Division of Cancer Epidemiology, McGill University.

Recent advances in “-omics” technologies allow the simultaneous quantitation of thousands of features, revolutionizing the way that scientists can measure pathogenic processes or responses to therapies. Despite their potential to improve diagnostics and prediction methods in routine clinical care, these high-dimensional multi-faceted data still present significant challenges, including measurement errors, outliers, multivariate responses, and complex correlation structures. For example, genomics data, imaging scans and years of standard clinical lab tests are sometimes available from the same subject. Furthermore, many of these features may be inaccurately measured, as a consequence of technical limitations or errors in recording data. A central goal of this Collaborative Research Team is to develop and establish an advanced analytical framework for the study and integration of complex data in biomedical sciences, including advanced regularized regression methods, robust regularized instrumental variable methods, and matrix-valued causal models, all for high-dimensional settings. These advancements are essential for building useful models in precision medicine.

Team Members:

Sahir Bhatnagar, Assistant Professor, Departments of Radiology and Epidemiology & Biostatistics, McGill University

Dehan Kong, Assistant Professor, Department of Statistical Sciences, University of Toronto

Karim Oualkacha, Professeur agrégé, Département de mathématique, Université du Québec à Montréal

David Soave, Assistant Professor, Mathematics Department, Wilfrid Laurier University

Linbo Wang, Assistant Professor, Department of Statistical Sciences, University of Toronto

Brent Richards, William Dawson Professor, Lady Davis Institute for Medical Research, McGill University

Marie Hudson, Associate Professor, Lady Davis Institute for Medical Research, McGill University

Tom Blydt-Hansen, Associate Professor of Pediatrics, University of British Columbia. Director, Multi Organ Transplant Program, BC Children’s Hospital

Zhaolei Zhang, Professor, University of Toronto

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