The advent of high-throughput DNA sequencing has opened the possibility of detecting rare genetic variants that may be involved in complex diseases. To establish involvement of rare variants in complex traits, family samples are better suited than samples of unrelated subjects because, in a family, multiple affected members are more likely than unrelated affected individuals to carry the same rare variant from the basic principles of inheritance. A common need in these settings is to account for various forms of dependence structures in familial DNA sequence data. One source of dependence is the relationships among family members, either known or unknown to the investigators. Another is the association among variants located at nearby genomic regions, which is detectable through DNA-sequence patterns in families and populations. Yet another is the dependence among multiple traits influenced by similar genetic and environmental risk factors. The proposed workshop arrives at the right time to address these current issues.